5 Simple Statements About mif Explained
5 Simple Statements About mif Explained
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MIF is seriously involved with the event inflammation and most cancers; therefore, inhibitors of MIF really should be further investigated as these molecules might have the aptitude to lessen the rate at which tumors proliferate and metastasize.
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) as well as their association Together with the susceptibility or severity of various health conditions has served not simply to validate MIF’s position in disease development but opened the potential for making use of MIF
The receptor that mediated MIF action remained elusive until finally a analyze in 2003, which utilized a cDNA library and fluorescently conjugated MIF to display for your receptor and recognized CD74 because the MIF receptor. The authors explained that MIF certain to the extracellular domain of CD74, leading to extracellular sign-regulated kinase (ERK) pathway activation (25).
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